Brain Tumor Research and Treatment  2014;2(1):36-38

doi:10.14791/btrt.2014.2.1.36

Glioblastoma in a Patient with Neurofibromatosis Type 1: A Case Report and Review of the Literature.

Tae Seok JEONG 1 ; Gi Taek YEE

Affiliations

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Keywords

Glioblastoma; Neurofibromatosis type 1; CCRT; Temozolomide

Country

Republic of Korea

Language

English

Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited familial tumor syndrome. Benign tumors such as pilocytic astrocytoma, optic glioma make up the majority of intracranial neoplasms in patients with NF1. There have only been a handful of cases in which adult glioblastoma presented with NF1. A 32-year-old male presented with headache and radiological studies showing a high grade intra-axial tumor. The patient underwent gross total surgical excision and the pathology revealed glioblastoma. After the surgery, he received concomitant chemo-radiotherapy with temozolomide and adjuvant temozolomide chemotherapy. We report a NF1 patient who developed glioblastoma and reviewed related articles.