Erectile dysfunction has a high incidence rate and is a difficult-to-treat condition in male urology.The synergistic effect of nerves,endothelium,and smooth muscles plays a crucial role in penile erection.However,the role of the many fibroblasts in the corpus cavernosum of the penis during erection is often overlooked.Fibroblasts are at the center of the cellular and molecular network in the corpus cavernosum of the penis,regulating the dynamic balance of the cavernosal microenvironment and mediating penile erection,thus providing a novel target for treating erectile dysfunction.Blood stasis primarily causes erectile dysfunction,thereby serving as a crucial pathological factor leading to the imbalance of the cavernosal microenvironment.Blood stasis also corresponds to the microscopic pathological changes in the corpus cavernosum of patients with erectile dysfunction.Therefore,this study explored the correlation between fibroblast-mediated penile erection and traditional Chinese medicine theories,integrating it with clinical practice.This study proposes that activating blood and resolving stasis can regulate the cavernosal microenvironment and improve fibroblast-mediated erectile dysfunction.This study also provides novel insights for treating erectile dysfunction with traditional Chinese medicine.