Cancer Research on Prevention and Treatment 2024;51(8):625-629

doi:10.3971/j.issn.1000-8578.2024.24.0044

Research Progress on Gene Polymorphisms Related to Osteosarcoma

Peng ZHANG 1 ; Kai CHEN ; Lingling HUANG ; Jinyan LIU ; Wen TIAN

Affiliations

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Keywords

Osteosarcoma; Susceptibility; Single nucleotide polymorphisms; Biomarkers; Genome-wide asso-ciation study

Country

China

Language

Chinese

Abstract

Osteosarcoma,which primarily affects children and adolescents,is a highly malignant bone tumor with high rates of disability and mortality.Therefore,the exploration of biological markers related to its occurrence,development,and prognosis is crucial.Genome-wide association studies have revealed the vital role of genetic polymorphisms in the pathogenesis of osteosarcoma.This study aims to provide new insights into reliable biomarkers of osteosarcoma through the analysis of the functional single-nucleotide polymor-phisms of tumor-related genes.