Cancer Research on Prevention and Treatment 2024;51(7):594-599

doi:10.3971/j.issn.1000-8578.2024.24.0082

Progress of Research on ABC Transporters in Tumor Multidrug Resistance

Xiaoke XING 1 ; Shuxian WANG ; Juanjuan LI ; Qibin SONG ; Pingfeng ZHANG

Affiliations

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Keywords

ABC transporter; Transmembrane transport; MDR; Tumor

Country

China

Language

Chinese

Abstract

The ATP-binding cassette(ABC)transporter superfamily comprises membrane proteins that efflux various substrates across extra-and intracellular membranes.Among them,ABCB1,ABCG2,and ABCC1 are directly linked to tumor multidrug resistance(MDR).This review provides an overview of the current understanding on the novel mechanisms and functions of ABCB1,ABCG2,and ABCC1 transporters in tumor MDR,discusses the latest strategies to target these transporters,and explores further opportunities to overcome MDR.