JOURNAL OF RARE DISEASES 2024;3(2):187-194

doi:10.12376/j.issn.2097-0501.2024.02.006

Advances in the Diagnosis and Treatment of Cushing's Syndrome

Cen LIU 1 ; Zinan ZHAO ; Di CHEN ; Xin HU

Affiliations

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Keywords

Cushing's syndrome; diagnosis; individualized treatment; orphan drugs; osilodrostat; pasireotide; mifepristone

Country

China

Language

Chinese

Abstract

Cushing's syndrome(CS),an endocrine disorder resulting from excessive glucocorticoid se-cretion by the adrenal cortex,poses significant challenges to both diagnosis and treatment.The diagnostic process involves comprehensive evaluation,combining laboratory tests and imaging studies for screening,quali-fication,and localization.Surgical intervention remains the primary treatment approach,although pharmacologi-cal therapy also plays a crucial role.With an increasing understanding of the pathogenesis of CS,more potential targets for orphan drug development have been discovered.This article summarizes the current status of diagnosis and treatment for CS and provides an outlook on future research directions.