In recent years, increasing clinical evidence has been accumulated to support the diagnosis and treatment of post transplantation diabetes mellitus (PTDM), especially the advent of novel hypoglycemic drugs and glucose monitoring technologies, which further promotes the advancement of diagnosis and treatment of PTDM. To elaborate the use of hypoglycemic drugs in PTDM, Diabetology Committee of Chinese Research Hospital Association, Chinese Diabetes Society and Diabetes Branch of Beijing Medical Association jointly organized relevant experts to compile Expert consensus on the use of hypoglycemic drugs in post transplantation diabetes mellitus (2024 Edition), which mainly focuses on the hypoglycemic mechanism, recommended intensity, cautions in clinical application and the interaction with immunosuppressants, aiming to further enhance clinical management level for PTDM patients and improve clinical outcomes. The release of this expert consensus will contribute to standardizing clinical diagnosis and treatment of PTDM.