Chinese Journal of Natural Medicines (English Ed.) 2023;21(8):619-630

doi:10.1016/S1875-5364(23)60464-9

Antimalarial and neuroprotective ent-abietane diterpenoids from the aerial parts of Phlogacanthus curviflorus.

Jia LI 1 ; Xiao MENG 1 ; Chengyue YIN 1 ; Lixia ZHANG 1 ; Bin LIN 2 ; Peng LIU 3 ; Lingjuan ZHU 1 ; Haifeng WANG 1 ; Hongwei LIU 4 ; Xue ZHANG 5 6 ; Xinsheng YAO 7

Affiliations

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Keywords

Acathaceae; Antimalarial activity; Neuroprotective effect; Phlogacanthus curviflorus; ent-Abietane diterpenoids

Country

China

Language

English

Abstract

Six new ent-abietane diterpenoids, abientaphlogatones A-F (1-6), along with two undescribed ent-abietane diterpenoid glucosides, abientaphlogasides A-B (7-8) and four known analogs were isolated from the aerial parts ofPhlogacanthus curviflorus (P. curviflorus). The structures of these compounds were determined using high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), one-dimensional and two-dimensional nuclear magnetic resonance (NMR) spectroscopy, electronic circular dichroism (ECD) spectra, and quantum chemical calculations. Notably, compounds 5 and 6 represented the first reported instances of ent-norabietane diterpenoids from the genus Phlogacanthus. In the β-hematin formation inhibition assay, compounds 2, 4, 7-10, and 12 displayed antimalarial activity, with IC50 values of 12.97-65.01 μmol·L-1. Furthermore, compounds 4, 5, 8, and 10 demonstrated neuroprotective activity in PC12 cell injury models induced by H2O2 and MPP+.