Effects of Ondansetron on the Neuromuscular Block of Vecuronium, Rocuronium or Atracurium in a Rat Phrenic Nerve-Hemidiaphragm Preparation.
10.4097/kjae.2003.45.5.650
- Author:
Si Young OK
1
;
Sun Chong KIM
;
Soon Im KIM
;
Jeong Seok LEE
;
Jai Yun JUNG
;
Kyung Ho HWANG
;
Sung Yell KIM
Author Information
1. Department of Anesthesiology, Soonchunhyang University Hospital, Seoul, Korea. soonnim@hosp.sch.ac.kr
- Publication Type:In Vitro ; Original Article
- Keywords:
atracurium;
neuromuscular transmission;
ondansetron;
rocuronium;
vecuronium
- MeSH:
Animals;
Atracurium*;
Colon, Sigmoid;
Neuromuscular Blockade*;
Neuromuscular Nondepolarizing Agents;
Ondansetron*;
Postoperative Nausea and Vomiting;
Rats*;
Receptors, Serotonin, 5-HT3;
Vecuronium Bromide*
- From:Korean Journal of Anesthesiology
2003;45(5):650-655
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Ondansetron, a 5-HT3 receptor antagonist, is widely used for the prevention of postoperative nausea and vomiting. However, the interaction of ondansetron with non-depolarizing muscle relaxants have not been reported until now. Therefore we studied the effects of ondansetron on the neuromuscular block of vecuronium, rocuronium or atracurium in vitro. METHODS: A square wave 0.1 Hz supramaximal stimuli was applied to the phrenic nerve-hemidiaphragm preparation of a rat, and the twitch height response was recorded mechanomyographically. We measured cumulative concentration response curves of vecuronium, rocuronium or atracurium alone and after pretreating with ondansetron (1microgram/ml). We also measured the effects of ondansetron. The EC50's and EC90's of these muscle relaxants alone and after pretreatment with ondansetron were calculated using an inhibitory sigmoid Emax model. RESULTS: Ondansetron depressed the twitch height in a dose-dependent manner, and its potency was lower than the muscle relaxants. The EC50 and EC90 of ondansetron were 14.7microgram/ml and 33.4microgram/ml, respectively. Pretreated ondansetron (1microgram/ml) significantly reduced the EC50's and EC90's of vecuronium, rocuronium and atracurium (P<0.05). CONCLUSIONS: Ondansetron itself may have neuromuscular blocking properties, and it significantly enhances the neuromuscular blocks induced by vecuronium, rocuronium or atracurium.
