In vivo delivery process and regulating mechanisms of lipid-based nanomedicines
10.16438/j.0513-4870.2023-0453
- VernacularTitle:脂质纳米药物体内递送过程及调控机制
- Author:
Tian-hao DING
1
;
Er-can WU
2
;
Chang-you ZHAN
3
Author Information
1. School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
2. School of Pharmacy, Fudan University, Shanghai 201203, China
3. School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; School of Pharmacy, Fudan University, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
lipid-based nanomedicine;
italic>in vivo delivery process;
protein corona;
regulatory mechanism;
intervention strategy
- From:
Acta Pharmaceutica Sinica
2023;58(8):2283-2291
- CountryChina
- Language:Chinese
-
Abstract:
Lipid-based nanocarrier is a classic drug delivery system with great biocompatibility and biodegradability. It can effectively reduce the toxicity of anti-tumor and anti-infective drugs in clinical practice. However, it has not yet met the clinical demand for enhanced therapeutic efficacy, and the clinical application is still very limited. The complex in vivo delivery process of lipid-based nanomedicine and the reciprocal interactions with body lead to unexpected changes in in vivo performance of nanomedicine and seriously hinder clinical translation. Therefore, the in-depth study of the relationships among intrinsic properties of lipid-based nanomedicine, the in vivo delivery process, and the regulatory mechanisms will not only provide guidance for the rational design of nanocarriers, but also promote the clinical translation and precision medicine of new lipid-based nanomedicine. In this review, we summarize the in vivo delivery process, regulating factors and intervention strategies for the in vivo delivery of lipid-based nanomedicine.
