Gut microbiota as a target for traditional Chinese medicine in the treatment of cardiovascular disease: potential mechanisms and therapy strategies
10.16438/j.0513-4870.2023-0261
- VernacularTitle:肠道菌群作为中药治疗心血管疾病的靶标: 潜在的机制和治疗策略
- Author:
Wan-qi LE
1
;
Jing-yu LIAO
1
;
Yu-hao ZHANG
2
;
Gao-song WU
1
;
Wei-dong ZHANG
3
Author Information
1. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China
3. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China; School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- Publication Type:Research Article
- Keywords:
gut microbiota;
metabolite of gut microbiota;
cardiovascular disease;
traditional Chinese medicine;
mechanism of action
- From:
Acta Pharmaceutica Sinica
2023;58(8):1988-1999
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease (CVD) is a major contributor to patient deaths worldwide, and its pathogenesis is complex and mortality rates are increasing every year. Numerous researches have shown that the gut microbiota and its metabolites were closely associated with the development of CVD, and gut microbiota was expected to be a potential new target for the treatment of CVD. Traditional Chinese medicine (TCM), characterized by its multi-component, multi-target and integrity, can play a therapeutic role in CVD by regulating the gut microbiota, which has obvious advantages in stabilizing the disease, improving heart function and enhancing quality of life, and is an ideal intestinal microecological regulator. Therefore, this review will mainly discuss the intimate association of gut microbiota and its metabolites with CVD, and the therapeutic strategies of TCM targeting gut microbiota to improve CVD, including regulating the composition of gut microbiota, protecting the intestinal mucosal barrier, influencing the intestinal immune function and modulating the metabolites of gut microbiota, in order to provide a reference for the research of TCM targeting gut microbiota for CVD.
