Second metabolites comparative analysis of Codonopsis pilosula (Franch.) Nannf. from different origins based on extensively targeted metabolomics
10.16438/j.0513-4870.2023-0724
- VernacularTitle:基于广泛靶向代谢组学的不同产地党参次生代谢产物比较分析
- Author:
Ling-yu LI
1
;
De-fu WANG
1
;
Zhen-fang LI
1
;
Shao-fei SHEN
1
;
Hong-ling TIAN
2
;
Yan-bing NIU
1
Author Information
1. College of Life Sciences, Shanxi Agricultural University, Taigu 030801, China
2. Institute of Industrial Crops, Shanxi Agricultural University, Taiyuan 030031, China
- Publication Type:Research Article
- Keywords:
italic>Codonopsis pilosula (Franch.) Nannf.;
metabolomics;
secondary metabolite;
ifferent origin;
quality
- From:
Acta Pharmaceutica Sinica
2023;58(11):3421-3427
- CountryChina
- Language:Chinese
-
Abstract:
We performed an extensively targeting metabolomic detecting using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) to compare the secondary metabolites in Dang shen [Codonopsis pilosula (Franch.) Nannf.] from Shanxi and Gansu provinces. The findings showed that 161 secondary metabolites in 6 groups (phenolic acids, flavonoids, lignans and coumarins, alkaloids, terpenoids, others) were found from Dang shen in Changzhi city of Shanxi province and Dingxi city of Gansu province. There were 98 secondary metabolites which is differed significantly. In comparison to Dingxi city, 33 different secondary metabolites of Dang shen in Changzhi city had a greater relative content, whereas relative content of 65 different metabolites in Dingxi city was higher. Metabolic pathway enrichment analysis revealed that phenolic acids and flavonoids were significantly different in the secondary metabolites of Dang shen from different producing places. This may be one of the reasons for the difference in the quality of Dang shen in Shanxi and Gansu provinces. This work compared and analyzed the secondary metabolites of Dang shen from Dingxi city in Gansu province and Changzhi city in Shanxi province for the first time, which lays the foundation for further study on the quality of Dang shen.
