The role of lipid peroxidation in modulating immune function
10.16438/j.0513-4870.2023-0592
- VernacularTitle:脂质过氧化在免疫功能调节作用中的研究进展
- Author:
Xin-xing CHEN
1
;
Shu-hua OUYANG
1
;
Hiroshi KURIHARA
1
;
Yi-fang LI
1
;
Yan-ping WU
1
;
Rong-rong HE
1
Author Information
1. Guangdong Engineering Research Center of Chinese Medicine and Disease Susceptibility, Jinan University, Guangzhou 510632, China; Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
- Publication Type:Research Article
- Keywords:
lipid peroxidation;
immune cell;
ferroptosis;
immunotherapy
- From:
Acta Pharmaceutica Sinica
2023;58(11):3230-3241
- CountryChina
- Language:Chinese
-
Abstract:
The immune system plays a pivotal role in the pathogenesis and progression of diseases. Lipid peroxidation, as a key effector molecule in the execution of ferroptosis, exerts critical effects on the functionality and survival of various immune cells and is involved in the pathological processes of multiple diseases. There is accumulating evidence suggesting the presence of ferroptosis in immune cells as well. Lipid peroxidation is closely associated with immune cell function. Accumulation of lipid peroxidation products in immune cells can lead to ferroptosis, directly impacting immune cell function. Non-immune cells, through lipid peroxidation-mediated cell death, release signaling molecules that regulate immune cell function. They jointly influence the body's homeostasis. This article provides a comprehensive review of the latest research progress on the regulatory role of lipid peroxidation in immune function. It analyzes the relationship between lipid peroxidation and immune cells, and provides a theoretical foundation for potential strategies targeting cellular lipid peroxidation and immunotherapy in the treatment of diseases.
