Mechanisms and research progress of targeted therapies on regulation of autophagy by natural compounds from traditional Chinese medicine
10.16438/j.0513-4870.2023-0425
- VernacularTitle:中药来源的天然化合物调控自噬机制及靶向治疗研究进展
- Author:
Lei-lei FU
1
;
Yuan-yuan YANG
2
;
Bo LIU
3
;
Hai-yang YU
4
Author Information
1. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
2. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China; State Key Laboratory of Biotherapy and Cancer Center, Sichuan University, Chengdu 610041, China
3. State Key Laboratory of Biotherapy and Cancer Center, Sichuan University, Chengdu 610041, China
4. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
- Publication Type:Research Article
- Keywords:
autophagy;
traditional Chinese medicine;
natural compound;
PI3K/AKT/mTOR;
mitogen-activated protein kinases
- From:
Acta Pharmaceutica Sinica
2023;58(9):2569-2580
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is an important physiological process that can degrade cell components and maintain cell homeostasis, divided into three types including macroautophagy, microautophagy and chaperon-mediated autophagy generally, and macroautophagy is the most common form. Autophagy can affect the progression of a variety of diseases, such as cancer, neurodegenerative diseases, heart-related diseases, and autoimmune diseases, etc. However, autophagy can promote or inhibit diseases in different circumstances because of the dual roles of autophagy. Therefore, targeted regulating autophagy may be a potential treatment plan for diseases in specific stages of disease development. Now, with the development of traditional Chinese medicine (TCM) resources and the deepening of researches on the modern utilization of TCM, many active compounds from TCM have been discovered that can target autophagy to exert pharmacological activity. Most of the natural compounds activate or inhibit autophagy by affecting the classical PI3K/AKT/mTOR autophagy pathway. In addition, some compounds can also affect autophagy through MAPKs signaling pathways such as MEK/ERK, JNK and p38MAPK. These active compounds exert various biological activities by regulating autophagy, including anti-tumor, inhibiting neurodegenerative diseases, protecting cardiomyocytes, and relief of inflammatory response. In this review, we summarized the active compounds in TCM that affect autophagy by targeting different signaling pathways and their mechanisms of regulating autophagy, also introduced the effects of active compounds on diseases after affecting autophagy. Finally, this paper summarized and prospected the development of targeted autophagy for the treatment of diseases by TCM compounds, hoping to provide clues for subsequent exploration and research.
