Research progress on metabonomics of traditional Chinese medicine in the treatment of ulcerative colitis
- VernacularTitle:中药治疗溃疡性结肠炎的代谢组学研究进展
- Author:
Lin BAI
1
;
Yangyang WANG
1
;
Jingyi BAI
2
;
Xinli WEN
2
Author Information
1. Dept. of Traditional Chinese Medicine，the First College of Clinical Medicine，Shaanxi University of Chinese Medicine，Shaanxi Xianyang 712046，China
2. The Second Department of Spleen and Stomach Diseases，Shaanxi Provincial Hospital of Chinese Medicine，Xi’an 710003，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
ulcerative colitis;
metabonomics;
metabolite;
metabolic pathway
- From:
China Pharmacy
2023;34(22):2810-2816
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE Ulcerative colitis （UC）， as a common and refractory disease of the digestive system， has always been a hot and difficult point in medical research. Traditional Chinese medicine has the advantages of good efficacy， high safety and not easy to relapse after drug withdrawal in the treatment of UC， but the mechanism has not been fully elucidated. Metabonomics looks for potential biomarkers and metabolic pathways from the point of view of the endogenous dynamic metabolism of the whole body， which is helpful to evaluate the efficacy of drugs and explore related mechanisms. Metabolomics studies on the treatment of UC with traditional Chinese medicine have shown that traditional Chinese medicine formulas， single herbs and herbs monomers act on various related pathways such as amino acid metabolism， lipid metabolism and energy metabolism by regulating endogenous metabolites in the body， thereby inhibiting immune inflammatory reactions， improving oxidative stress， reducing intestinal sensitivity， regulating intestinal microbiota， repairing intestinal mucosal damage， and restoring normal metabolic activity in the body. However， further screening and validation of relevant metabolic markers are needed.
