Advances in the treatment of hypertrophic cardiomyopathy with cardiac myosin inhibitors
- VernacularTitle:心肌肌球蛋白抑制剂治疗肥厚型心肌病的研究进展
- Author:
Ye YUAN
1
;
Zhenzhen YANG
1
;
Bo YU
1
;
Qian SUN
1
;
Zhiqing ZHANG
1
Author Information
1. Dept. of Pharmacy，the Second Hospital of Hebei Medical University，Shijiazhuang 050000，China
- Publication Type:Journal Article
- Keywords:
cardiac myosin inhibitors;
hypertrophic obstructive cardiomyopathy;
Mavacamten;
Aficamten;
molecular-targeted
- From:
China Pharmacy
2023;34(21):2684-2688
- CountryChina
- Language:Chinese
-
Abstract:
In recent years， with the increasing understanding of the genetic mechanisms of hypertrophic cardiomyopathy， novel molecular-targeted drugs Mavacamten and Aficamten are two cardiac myosin inhibitors currently approved by the FDA for the treatment of hypertrophic obstructive cardiomyopathy. Both of them have a similar mechanism of action and can selectively bind to different variable sites of cardiac myosin to inhibit cardiac myosin， thus reducing myocardial hypercontractility. Relevant clinical studies have also shown that both drugs can reduce patients’ left ventricular outflow tract pressure gradient， the levels of N-terminal pro-B-type natriuretic peptide and cardiac troponin I as cardiac markers， and improve New York Heart Association （NYHA） cardiac function class. They are safe， have mild adverse reactions， and can be tolerated by patients. Compared to Mavacamten， Aficamten， as a structurally optimized product， has a shorter half-life and fewer drug-drug interactions， which is more conducive to drug- targeted dose titration.
