Molecular Imaging in Breast Cancer
10.1007/s13139-019-00614-w
- Author:
Daniela MILADINOVA
1
Author Information
1. Institute of Pathophysiology and Nuclear Medicine Academician Isak S.Tadzer, Faculty of Medicine, University Ss. Cyril and Methodius in Skopje, Mother Theresa 17, 1000 Skopje, North Macedonia. danielamiladinova@medf.ukim.edu.mk
- Publication Type:Review
- From:Nuclear Medicine and Molecular Imaging
2019;53(5):313-319
- CountryRepublic of Korea
- Language:English
-
Abstract:
Breast cancer (BC) is themost common cancer among females withmore than 2 million new cases diagnosed worldwide in 2018. Although the prognosis in the majority of cases in the early stages combined with appropriate treatment is positive, there are still about 30% of patients who will develop locoregional diseases and distant metastases. Molecular imaging is very important in the diagnosis, staging, follow-up, and radiotherapy planning. Additionally, it is useful in characterizing lesions, prognosis, and therapy response in BC patients. Nuclear medicine imaging modalities (SPECT and PET) are of indispensable importance in diagnosis (positron emission mammography), staging (sentinel lymph node detection), and follow-up with ¹â¸F-FDG and tumor characterization. Among many available PET tracers, the most commonly used are ¹â¸F-FLT, ¹â¸F-FES, ¹â¸F-FDHT, â¶â´Cu DOTA trastuzumab (bevacizumab), â¶â¸Ga-PSMA, â¶â¸Ga-RM2 (gastrin-releasing peptide receptor), ¹â¸F-fluorooctreotide (SSTR), and â¶â¸Ga-TRAP (RGD)-3αvβ3-integrin. Molecular imaging helps in evaluation of tumor heterogeneity, allowing a shift from one-size-fits-all-approach to era of personalized medicine and precision oncology.
