Role of DNA methylation in the pathogenesis of ophthalmic diseases
10.3980/j.issn.1672-5123.2023.11.08
- VernacularTitle:DNA甲基化修饰在眼科疾病发病进程中的作用研究进展
- Author:
Zhao-Hui YANG
1
;
Jin-Peng LIU
1
;
Da-Dong GUO
1
;
Hong-Sheng BI
1
Author Information
1. Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
epigenetic inheritance;
DNA methylation;
diabetic retinopathy;
uveitis;
myopia
- From:
International Eye Science
2023;23(11):1811-1815
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and development of many eye diseases are closely related to genetic and environmental factors, among which epigenetic modification is an important bridge connecting genetic and environmental factors. It can affect the levels of related genes by influencing gene transcription or translation, thereby playing a role in the pathogenesis of ocular diseases. DNA methylation is an important part of epigenetic modification which is usually regulated by three processes: de novo methylation, maintenance methylation, and demethylation, and plays an essential role in regulating gene expression. At present, researchers have conducted that DNA methylation plays an important role in repair of damage to corneal endothelium, mitochondrial dynamics regulation and diabetic retinopathy, oxidative stress response and cataracts and other eye diseases, providing new ideas in the treatment of related ocular diseases. This study presented a brief review of the role of DNA methylation in the development of related ocular diseases and provided new perspectives and directions for the screening, diagnosis, and treatment of eye diseases.
