Research progress on function and molecular mechanism of transcription factor ELK1 of Ets
10.13200/j.cnki.cjb.003891
- VernacularTitle:Ets转录因子ELK1功能及其作用机制的研究进展
- Author:
ZHAO Yuanshen
- Publication Type:Journal Article
- Keywords:
ELK1;
Ets family;
MAPK/ERK signaling pathway;
Tumor cells;
Stem cells;
Neural cells
- From:
Chinese Journal of Biologicals
2023;36(5):614-618+625
- CountryChina
- Language:Chinese
-
Abstract:
Ets transcription factor ELK 1,a member of the ternary complex factor(TCF) subfamily in the Ets family,is directly downstream signal of MAPK/ERK pathway and is activated by phosphorylation to execute the function of ERK signal.ELK1,which is highly expressed and phosphorylated in stem cells and tumor cells,plays a role in promoting proliferation,inhibiting apoptosis and differentiation in stem cells.In tumor cells,ELK1 has shown to promote proliferation,migration,and inhibit apoptosis.In neural cells,ELK1 is involved in long-term memory,learning,addiction and other functions.In this paper,the research progress on the main structure and basic biological characteristics of ELK1,the function and mechanism of ELK 1 in tumor cells,stem cells and nerve cells are reviewed in order to provide new ideas for the follow-up research.
