Construction and management model practice of a patient-derived xenograft model platform
10.3760/cma.j.cn113565-20221103-00209
- VernacularTitle:人源化移植瘤动物模型平台管理模式的建设与实践
- Author:
Lan MI
1
;
Ning DING
;
Lixia FENG
;
Kun ZHANG
;
Lijun WANG
;
Jun ZHU
;
Yuqin SONG
Author Information
1. 北京大学肿瘤医院暨北京市肿瘤防治研究所淋巴肿瘤内科 恶性肿瘤发病机制及转化研究教育部重点实验室 100142
- Keywords:
Animal models;
Research management;
Clinical trials;
Oncology
- From:
Chinese Journal of Medical Science Research Management
2023;36(2):144-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective:In the era of precision medicine, there is an urgent need for a preclinical evaluation method with a high cost-benefit ratio to improve the effectiveness and value of clinical trials.Methods:Taking clinical needs and scientific research purposes as the starting point, the platform focused on four aspects of project management, information retrieval, quality control, and practical application, and introduced in detail the management practice of building a patient-derived xenograft model platform system.Results:With the support of the institutional system, quality control system, and information system, the patient-derived xenograft model platform was formed with standardization as the core. With the assistance of this platform and scientific research management, as of December 2021, there are 48 animal models of patient-derived xenograft in the database. In total of 6 SCI scientific and technological articles were published using these animal models, with a total impact factor of 36.77 (the highest single article was 7.333). In total of 6 direct industrial projects, 6 clinical trial-related projects, and 4 NSFC projects were approved with a total research fund of 1.5 million yuan.Conclusions:Continuous construction and improvement of the existing platform will help promote the development of basic research translation and clinical research in the field of oncology, and accelerate the development of new oncological diagnosis and treatment models, thereby benefiting more patients.
