Mechanism and clinical value of long non-coding RNA in the development of atherosclerosis

VernacularTitle:长链非编码RNA在动脉粥样硬化发生发展中的作用机制及临床价值
Author: Xin YANG ¹ ; Yanwei HU
Author Information

1. 广州市妇女儿童医疗中心检验科，广州　510623
Keywords: Atherosclerosis; Long non-coding RNA; Cardiovascular diseases; Biomarker
From: Chinese Journal of Laboratory Medicine 2023;46(7):741-747
CountryChina
Language:Chinese
Abstract: Long non-coding RNAs (lncRNA) are a class of non-coding RNA with a length of more than 200 nucleotide, it is known that lncRNA can regulate gene expression at epigenetic, transcriptional and post transcriptional levels. Recent studies have shown that lncRNA is an important regulator of atherosclerosis (AS) and plays an important role in the pathogenesis of AS. This paper aims to comprehensively explore the mechanism of lncRNA in AS and summarize new biomarkers for AS diagnosis, we focused on the research progress of some key lncRNA in regulating the function of endothelial cells, smooth muscle cells, and monocytes and macrophages through literature review. Furthermore, this review discusses the potential clinical diagnostic value of lncRNA as biomarker in coronary heart disease (CHD), acute myocardial infarction, and heart failure (HF). LncRNA is expected to become a new class of clinically relevant biomarker, which might be useful for the prediction, diagnosis, prognosis and risk stratification of AS and cardiovascular diseases.