Clinical effects and pathological characteristics of gastric tumors of fundic gland type treated with endoscopic submucosal dissection
10.3760/cma.j.cn321463-20221012-00520
- VernacularTitle:胃底腺型肿瘤内镜黏膜下剥离术治疗的临床效果评价及病理学特点分析
- Author:
Xiao LIU
1
;
Jianfeng YU
;
Yanbin WANG
;
Xinjuan LIU
;
Zhen LIU
;
Donglei ZHANG
;
Jianyu HAO
Author Information
1. 首都医科大学附属北京朝阳医院消化内科，北京 100020
- Keywords:
Gastric fundus;
Gastric adenocarcinoma of fundic gland type;
Oxyntic gland adenoma;
Endoscopic submucosal dissection
- From:
Chinese Journal of Digestive Endoscopy
2023;40(4):308-312
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the clinical effects and pathological characteristics of gastric tumors of fundic gland type treated with endoscopic submucosal dissection (ESD), data of 7 patients who treated by ESD and whose postoperative pathology indicated gastric adenocarcinoma of fundic gland type or gastric oxyntic gland adenoma in Endoscopic Center of Beijing Chao-Yang Hospital of Capital Medical University from August 2018 to June 2022 were collected. The clinical characteristics, surgical complications, preoperative and postoperative pathological data and follow-up data were evaluated. The lesions of the 7 patients were all located at gastric fundus, and were treated by ESD successfully. No bleeding, perforation or other complications occurred during and after the operation. Postoperative pathology showed that tumor cells originated from deep mucosa with an invasive growth pattern. Most of tumor surfaces were covered with normal concave epithelium. Tumors infiltrated into submucosa in 4 patients, and submucosa infiltration depth was more than 500 μm (550 μm) in 1 patient. Immunohistochemistry showed that MUC-6 was diffusely positive, indicating that the tumor originated from the main cell source. The expressions of MUC-2, MUC-5AC, CDX-2, CD10, and CgA were negative in all cases. With the mean follow-up time of 21 months, the ulcer healed well after the operation, with no recurrence. Gastric tumors of fundic gland type have relatively unique biological characteristics, and ESD is the preferred treatment. In addition, the histological characteristics can be used to differentiate from other gastric tumors by immunohistochemistry.
