Research progress of human milk exosomes and their effects on intestinal mucosal barrier in neonates
10.3760/cma.j.cn113903-20230331-00192
- VernacularTitle:人乳外泌体及其对新生儿肠道黏膜屏障的影响
- Author:
Yuqiong CHEN
1
;
Xiangdong OUYANG
;
Gen CHEN
Author Information
1. 湖南省郴州市第一人民医院新生儿科，郴州 423000
- Keywords:
Milk, human;
Exosomes;
Intestinal mucosa;
Breast feeding;
Infant, newborn
- From:
Chinese Journal of Perinatal Medicine
2023;26(7):561-565
- CountryChina
- Language:Chinese
-
Abstract:
Human breast milk-derived exosomes (HMDEs) are newly discovered active signaling vesicles in breast milk, which are rich in nucleic acids, proteins, and lipids. These exosomes play an essential role in the development and maturation of the intestinal mucosal barrier in newborns. In addition, HMDEs possess distinctive properties that allow for remodeling and modification, thereby are expected to provide more efficient prevention and treatment strategies for neonatal intestinal diseases. This article aims to provide a comprehensive review of the origin, isolation, identification, labeling, structural features, composition, and biological functions, and their unique impact on the intestinal mucosal barrier function in newborns.
