Advances of aerobic glycolysis in renal interstitial fibrosis
10.3760/cma.j.cn441217-20220621-00631
- VernacularTitle:肾间质纤维化中有氧糖酵解的研究进展
- Author:
Meng ZHANG
1
;
Lu ZHANG
;
Huiming WANG
Author Information
1. 武汉大学人民医院肾内科，武汉 430060
- Keywords:
Fibrosis;
Glycolysis;
Renal insufficiency, chronic;
Renal interstitium;
Metabolic reprogramming
- From:
Chinese Journal of Nephrology
2023;39(2):150-154
- CountryChina
- Language:Chinese
-
Abstract:
Aerobic glycolysis is a metabolic process in which cellular energy production favors the low-efficiency energy-producing glycolytic pathway in the presence of sufficient oxygen, reducing dependence on aerobic respiration, while producing energy rapidly and providing advantages for cell survival and proliferation. In recent years, several studies have shown that aerobic glycolysis is involved in the development of renal interstitial fibrosis (RIF) and involves various cell types such as fibroblasts, endothelial cells, renal tubular epithelial cells, pericytes, and inflammatory cells. Drugs targeting glycolysis may provide new ideas for the prevention and treatment of RIF. This article reviews the research progress of abnormal aerobic glycolysis in different cells and glycolytic intervention drugs in RIF.
