Research advance of mesenchymal stem cell-derived exosomes in graft-versus-host disease

VernacularTitle:间充质干细胞来源外泌体在移植物抗宿主病中的研究进展
Author: Huihui AN ¹ ; Lingling YU ; Tao WU
Author Information

1. 中国人民解放军联勤保障部队第九四〇医院血液病内科，兰州　730050
Keywords: Mesenchymal stem cells; Exosomes; microRNA; Allogeneic hematopoietic stem cell transplantation; Graft-versus-host disease
From: Chinese Journal of Organ Transplantation 2023;44(6):377-382
CountryChina
Language:Chinese
Abstract: Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewing differentiation, immunoactivity and anti-inflammatory potentials.Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently the most effective treatment for hematologic malignancies.However, the presence of graft-versus-host disease (GVHD) after transplantation has hindered the development of allo-HSCT.MSC-derived exosomes (MSC-exo) derived from mesenchymal stem cells have been confirmed to have broad therapeutic prospects in allo-HSCT and GVHD.This review focused upon immunomodulatory effects of MSC, biological activities of MSC-exo and research advances of MSC-exo on managing GVHD, aiming to provide new therapeutic rationales for GVHD in the future.