Regulatory role of autophagy in ferroptosis and its research advances in kidney injury
10.3760/cma.j.cn421203-20220623-00154
- VernacularTitle:自噬对铁死亡的调控作用及其在肾损伤中的研究进展
- Author:
Pingbao ZHANG
1
;
Ruiming RONG
Author Information
1. 复旦大学附属中山医院泌尿外科 上海市器官移植重点实验室，上海 200032
- Keywords:
Acute kidney injury;
Ischemia reperfusion injury;
Ferroptosis;
Autophagy;
Lipid peroxidation
- From:
Chinese Journal of Organ Transplantation
2023;44(4):252-257
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a conservative biological process of maintaining internal balances through degrading damaged proteins, organelles and intracellular pathogens.It may promote cell survival and accelerate cell death.Ferroptosis is a newly discovered regulated form of cell death characterized by lipid peroxidation and membrane damage in 2012.In recent years, more and more studies have demonstrated complex interactions between autophagy and ferroptosis.Various forms of cell death are regulated during the progression of kidney diseases.And autophagy and ferroptosis play important roles.However, potential connections between autophagy and ferroptosis in renal injury disease has not been fully elucidated.This review focused upon on the regulatory role of autophagy in ferroptosis and its possible link to renal injury, providing new theoretical rationales for researches on acute or chronic kidney injury.
