Clinical research advances of liver transplantation for patients with familial hypercholesterolemia
10.3760/cma.j.cn421203-20220727-00186
- VernacularTitle:肝移植治疗家族性高胆固醇血症的临床研究进展
- Author:
Lei ZHANG
1
;
Shaohua SONG
;
Zhiren FU
Author Information
1. 上海交通大学医学院附属瑞金医院普外科，上海 200025
- Keywords:
Familial hypercholesterolemia;
Liver transplantation;
Treatment
- From:
Chinese Journal of Organ Transplantation
2023;44(2):112-116
- CountryChina
- Language:Chinese
-
Abstract:
Familial hypercholesterolemia(FH)is an autosomal dominant disease.Homozygous FH patients tend to have a high incidence of severe arteriosclerotic cardiovascular disease during adolescence and die at ages of 20-30.Liver transplantation(LT)may correct the dysfunction of LDL receptor on hepatocytes, restore normal lipoprotein metabolism, arrest disease progression and improving patient outcomes.However, due to a great rarity of LT for FH, domestic transplantation centers lack the relevant clinical experiences.This review summarized some important issues of FH patients undergoing LT, such as indications, timing, donor sources, efficacies, complications and reusing diseased liver.The goal was to provide practical references for managing FH.
