Cellular senescence and type 2 diabetes
10.3760/cma.j.cn311282-20221014-00582
- VernacularTitle:细胞衰老与2型糖尿病
- Author:
Zhiwei HE
1
;
Xin HU
;
Jingwen YU
;
Yu CHEN
;
Chao LIU
Author Information
1. 南京中医药大学附属中西医结合医院内分泌科，南京 210028
- Keywords:
Cellular senescence;
Diabetes mellitus, type 2;
Pathogenesis;
Pancreatic β cell;
Adipocyte
- From:
Chinese Journal of Endocrinology and Metabolism
2023;39(6):532-537
- CountryChina
- Language:Chinese
-
Abstract:
Cellular senescence is a state in which cells enter permanent cell cycle arrest, which is characterized by senescence-associated secretory phenotype secretion, macromolecular damage, metabolic dysregulation and so on. Recent studies have shown a close relationship between cellular senescence and type 2 diabetes. On the one hand, the glycolipotoxic microenvironment of type 2 diabetes can accelerate cell senescence and accumulation. On the other hand, cellular senescence can promote the development of type 2 diabetes. For example, senescence of pancreatic β-cells leads to β-cell dysfunction and adipocytes senescence results in the secretion of pro-inflammatory cytokines, causing disturbances in lipid metabolism and exacerbating insulin resistance. Moreover, senescence of endothelial cells, retinal endothelial cells, and other cell types contributes to the occurrence of chronic complications in diabetes. Cellular senescence is not only an important factor in the onset of type 2 diabetes but also a consequence of its progression. Targeting cellular senescence holds promise as a new strategy for the treatment of type 2 diabetes.
