Irisin and skeletal muscle mitochondrial function and sarcopenia
10.3760/cma.j.issn.0254-9026.2023.07.023
- VernacularTitle:鸢尾素与骨骼肌线粒体功能及肌少症的关系
- Author:
Yinghui WANG
1
;
Ming TIAN
;
Yuehui WANG
Author Information
1. 吉林大学第一医院老年病科 吉林省老年疾病临床医学研究中心，长春 130021
- Keywords:
Muscle, skeletal;
Mitochondria, muscle;
Irisin;
Sarcopenia
- From:
Chinese Journal of Geriatrics
2023;42(7):872-876
- CountryChina
- Language:Chinese
-
Abstract:
Irisin is a muscle factor that plays a crucial role in exercise-induced metabolic responses.Recent studies have revealed that it can boost the metabolic rate of both myocytes and adipocytes, while also enhancing mitochondrial content and dynamics.This ultimately helps to safeguard skeletal muscle, promote muscle growth, and maintain optimal muscle function.Therefore, irisin has the potential to serve as both a predictor and a biomarker for sarcopenia.In this paper, we delve into the impact of irisin on skeletal muscle, specifically exploring the synergistic relationship between irisin and mitochondria.Additionally, we investigate the effectiveness of irisin in reversing and restoring muscle atrophy, ultimately establishing irisin as a valuable target for treating sarcopenia.
