Risk factors associated with diabetes retinopathy in patients with coronary heart disease
10.3760/cma.j.issn.0254-9026.2022.12.010
- VernacularTitle:合并冠心病患者的糖尿病性视网膜病变危险因素分析
- Author:
Yinan ZHAO
1
;
Yanju MIAO
;
Yingsheng ZHOU
Author Information
1. 首都医科大学附属北京安贞医院内分泌代谢科 北京市心肺血管疾病研究所 100029
- Keywords:
Diabetes mellitus;
Coronary disease;
Diabetic retinopathy;
Risk factors
- From:
Chinese Journal of Geriatrics
2022;41(12):1459-1463
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the risk factors for diabetic retinopathy(DR)in patients with coronary artery disease(CAD).Methods:353 patients with diabetes mellitus hospitalized at Beijing Anzhen Hospital between 2013 and 2015 were enrolled, including 96 patients with coronary artery disease(27%)and 156 patients with DR(44%).Medical history and examination/laboratory results of all patients were collected for analysis.Coronary artery disease was diagnosed according to coronary angiography.DR was diagnosed via ophthalmological examinations.The clinical characteristics of patients with and without DR were compared and contrasted between the groups.Results:Compared with patients without DR, patients with DR had a longer duration of diabetes, [15 years(10, 20) vs.8 years(4, 13), P<0.001]and a higher urine albumin/creatine ratio(UACR)[12.1 mg/g(3.2, 71.9) vs.4.8 mg/g(2.2, 3.5), P<0.001].Logistic regression analysis suggested that duration of diabetes( OR=1.107, 95% CI: 1.063~1.153, P<0.001)and UACR( OR=0.003, 95% CI: 1.001~1.006, P=0.008)were independent risk factors for DR.ROC curves revealed that a duration of diabetes >9.5 years or UACR>7.1 mg/g was significantly associated with DR.Also, of all patients with CAD, those with DR had a longer duration of diabetes[15 years(10, 20) vs.10 years(6, 15), P=0.002]and a higher percentage with hypertension(88.1% vs.67.6%, P=0.014).Hypertension history( OR=4.049, 95% CI: 1.099~14.925, P=0.036)and duration of diabetes( OR=1.159, 95% CI: 1.044~1.287, P=0.005)were independent risk factors for DR in patients with CAD.History of hypertension or a duration of diabetes>11.5 years was significantly associated with DR. Conclusions:In patients with coronary heart disease, hypertension history or a long duration of diabetes is significantly associated with an increased risk of DR.
