Correlation analysis between uranium exposure and renal injury
10.3760/cma.j.cn112271-20221129-00462
- VernacularTitle:血铀浓度与肾损伤的关联性研究
- Author:
Shengxiang ZHOU
1
;
Yan TANG
;
Peng TANG
;
Yangcan WANG
;
Shuxiang DENG
;
Minxue SHEN
;
Fei YANG
Author Information
1. 南华大学衡阳医学院公共卫生学院 湖南省典型环境污染与健康危害重点实验室，衡阳 421001
- Keywords:
Plasma uranium;
Renal injury;
Case-control;
Conditional logistic regression
- From:
Chinese Journal of Radiological Medicine and Protection
2023;43(4):276-283
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between plasma uranium concentration and renal injury.Methods:A case-control study was conducted in Hunan province, involving 102 renal injury cases and 102 matched controls. The association between plasma uranium concentration and renal injury was analyzed using conditional logistic regression models, and the dose-response relationship was analyzed through restricted cubic spline regression. The linear regression model and Spearman correlation were used to analyze the association between plasma uranium concentration and renal injury indicators.Results:The median of plasma uranium concentration was 8.94 ng/L in all subjects and 10.19 ng/L in the case group. The plasma uranium may be a risk factor for renal injury, with a dose-response relationship between the both representing nonlinear association ( χ2=5.15, P<0.05). The risk of renal injury was 4.21 times higher in the group exposed to highest uranium concentration than that in the group exposed to lowest uranium concentration. Plasma uranium concentration was closely related to glomerular filtration rate, serum creatinine and β 2-microglobulin ( r=0.211, -0.142, 0.195, P<0.05). Conclusions:The plasma uranium concentration is significantly associated with the renal injury, which may provide epidemiology evidence for the prevention of renal injury.
