Research progress on the role and mechanism of premature cellular senescence on wound healing in radiation-induced skin injury

VernacularTitle:细胞早衰对放射性皮肤损伤中伤口愈合的影响及机制研究
Author: Jie CHEN ¹ ; Mei TIAN ; Ling GAO
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1. 中国疾病预防控制中心辐射防护与核安全医学所　辐射防护与核应急中国疾病预防控制中心重点实验室，北京　100088
Keywords: Ionizing radiation; Premature cellular senescence; Radiation-induced skin injury; Wound healing
From: Chinese Journal of Radiological Medicine and Protection 2023;43(2):149-153
CountryChina
Language:Chinese
Abstract: Radiation skin injury can be induced by medical exposure, occupational exposure, and emergency exposure. Many relevant studies focused on the prevention and treatment of radiation-induced skin injury, but the underlying molecular mechanisms have not been fully clarified. It has been demonstrated that radiation-induced premature cellular senescence is involved in radiation skin injury. To discuss the relationship between radiation-induced premature cellular senescence and radiation-induced skin injury, this paper reviewed the mechanism of radiation-induced skin injury, the promotion of premature cellular senescence and related signal pathways, and the role of premature cellular senescence in wound healing.