Research progress in the role of mesenchymal stem cell sheets and their derivatives in bone defect repair

VernacularTitle:间充质干细胞片及其衍生材料在骨缺损修复中作用的研究进展
Author: Yulin ZHAO ¹ ; Yang LU ; Heng WANG ; Cheng CHEN ; Xiaoqing CHEN
Author Information

1. 南通大学医学院，南通　226001
Keywords: Tissue engineering; Bone regeneration; Extracellular matrix; Mesenchymal stem cells; Bone defects
From: Chinese Journal of Trauma 2023;39(5):465-472
CountryChina
Language:Chinese
Abstract: Bone defects are mostly caused by severe trauma, infection, tumor resection and congenital malformations, which adversely affect their health and quality of life. So far, the bone defects are mainly filled with autologous or allogeneic bone grafting, which has problems such as donor shortage, secondary bone injury and scarring. In recent years, the rise of bone tissue engineering has provided a new way for repair of bone defects, in which mesenchymal stem cell (MSC) sheets prepared by using the principle of tissue engineering can well solve the above problems of autologous or allogeneic bone grafting. With the development of preparation technology, new bone defect repair materials such as decellularized extracellular matrix (ECM) sheets and MSC/ECM clumps have been derived on the basis of MSC sheets. Therefore, the authors reviewed the preparation and the role of MSC sheets and their derivatives in bone defect repair, hoping to provide a reference for basic research and clinical treatment related to bone defect repair.