Research progress on the relationship between Ferroptosis and renal ischemia-reperfusion injury
10.3760/cma.j.cn431274-20220808-00786
- VernacularTitle:铁死亡与肾缺血再灌注损伤关系的研究进展
- Author:
Hong SU
1
;
Hong XU
;
Guobiao LIANG
Author Information
1. 遵义医科大学附属医院泌尿外科，遵义 563000
- Keywords:
Acute kidney injury;
Reperfusion injury;
Ferroptosis;
Cell death
- From:
Journal of Chinese Physician
2023;25(6):954-957
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a new type of programmed cell death, which is different from apoptosis, pyrodeath, necrosis and autophagy. It is characterized by the imbalance of cell iron homeostasis, which leads to the accumulation of reactive oxygen species and lipid peroxides, which exceeds the antioxidant capacity of cells and eventually leads to oxidative death of cells. Studies have shown that ferroptosis plays an important role in acute renal injury induced by renal ischemia-reperfusion and inhibition of ferroptosis can effectively alleviate renal ischemia-reperfusion injury. It is of great significance to study the relationship and mechanism of ferroptosis and renal ischemia-reperfusion injury to prevent acute renal function injury caused by renal ischemia-reperfusion injury in clinical work .
