Research progress in the treatment of sepsis with vitamin C
10.3760/cma.j.cn431274-20220418-00349
- VernacularTitle:脓毒症患者维生素C治疗的研究进展
- Author:
Shan LI
1
;
Heling ZHAO
;
Limin SHEN
Author Information
1. 华北理工大学研究生院，唐山 063000
- Keywords:
Sepsis;
Vitamin C;
Inflammation;
Oxidative stress
- From:
Journal of Chinese Physician
2023;25(1):148-152
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a host reaction disorder caused by infection, in which oxidative stress is involved in the mechanism of organ damage. Vitamin C deficiency caused by trauma and infection is very common in critically ill patients. As a highly effective antioxidant, vitamin C can alleviate oxidative stress, reduce the inflammatory response, protect endothelial cell function, and reduce platelet activation. However, no definite clinical study confirms that patients with sepsis can benefit significantly from vitamin C supplementation. In order to further explore the clinical value of vitamin C in patients with sepsis, this paper discusses the pathophysiology of sepsis, the physiological function and deficiency of vitamin C, the basic research and clinical trials of vitamin C.
