Research progress on biomarkers related to ACPA-negative rheumatoid arthritis
10.3760/cma.j.cn341190-20221215-01047
- VernacularTitle:ACPA阴性类风湿关节炎生物标志物相关研究进展
- Author:
Yi ZHANG
1
;
Shengli ZHOU
Author Information
1. 合肥市第二人民医院中医、风湿科，合肥 230011
- Keywords:
Arthritis, rheumatoid;
Autoimmune diseases;
Anti cyclic citrulline peptide antibody;
Biomarkers;
Serologic tests;
Diagnosis;
Review
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(7):1116-1120
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis (RA) is a group of heterogeneous autoimmune diseases with erosive arthritis as the main clinical feature. The pathogenesis of RA remains unclear. Autoantibodies can be detected in blood or synovial fluid in approximately 70% of patients with RA in the early stage of the disease. Anti-citrullinated protein antibody (ACPA) is the most commonly used autoantibody in the diagnosis of RA. However, ACPA is not a specific antibody for RA. The discovery and clinical application of serum ACPA-negative RA biomarkers is of positive significance for the early diagnosis and prognosis improvement of RA. This paper reviews the research progress of ACPA-negative RA biomarkers.
