Compatibility stability of cinepazide maleate injection and dopamine hydrochloride injection
10.3760/cma.j.cn341190-20220407-00291
- VernacularTitle:马来酸桂哌齐特注射液与盐酸多巴胺注射液的配伍稳定性研究
- Author:
Yue ZHOU
1
;
Hui TIAN
;
Weiwei CHU
;
Peng GONG
Author Information
1. 安徽医科大学第一附属医院国家中医药管理局中药化学三级实验室，合肥 230022
- Keywords:
Spectrophotometry,ultraviolet;
Drug stability;
Drug interactions;
Drug compatibility;
Cinepazide maleate;
Dopamine hydrochloride;
Temperature;
Time
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(3):384-387
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the compatibility stability of cinepazide maleate injection and dopamine hydrochloride injection and explore the basis for the combined application of cinnamazide maleate injection and dopamine hydrochloride injection.Methods:A method for determining cinnamazide maleate injection and dopamine hydrochloride injection was established using an ultraviolet-visible spectrophotometer and verified from March 1, 2021 to May 20, 2021. The color and pH value of the solution prepared using the two drugs were determined within 5 hours at room temperature. The content change of the prepared solution was determined using an ultraviolet-visible spectrophotometer.Results:The linear range of the mass concentration of cinnamazide maleate was 4.03 - 32.24 mg/L and the linear range of dopamine hydrochloride was 20 -120 mg/L. At 25 ℃, the color of the prepared solution did not change within 5 hours and the pH value was in the range of 4.43 ± 0.06, indicating that the pH of the prepared solution did not change markedly. The concentrations of cinnamazide maleate and dopamine hydrochloride were (98.23 ± 1.09)% and (99.96 ± 0.41)% respectively, indicating good stability.Conclusion:The prepared solution using cinepazide maleate injection and dopamine hydrochloride injection can be used within 5 hours at 25 ℃.
