Rational use of acid suppressant for stress ulcer in PICU
10.3760/cma.j.issn.1673-4912.2023.04.001
- VernacularTitle:PICU应激性溃疡抑酸剂的规范应用
- Author:
Wei LI
1
;
Haiyan GE
;
Dong QU
Author Information
1. 首都儿科研究所附属儿童医院重症医学科，北京 100020
- Keywords:
Stress ulcer;
Stress ulcer prophylaxis;
Proton pump inhibitor;
Histamine-2 receptor antagonist
- From:
Chinese Pediatric Emergency Medicine
2023;30(4):241-246
- CountryChina
- Language:Chinese
-
Abstract:
Stress-related digestive tract mucosal disease is a common complication in pediatric intensive care unit(PICU). It may progress to stress ulcer and severe ulcer bleeding, which may lead to death.Currently, stress ulcer prophylaxis is recommended for critically ill children with high risk factors for stress ulcer, and the most commonly used acid suppression drugs are proton pump inhibitor and histamine-2 receptor antagonist.However, excessive prophylactic acid suppression is common and can increase the risk of hospital-acquired pneumonia and clostridium difficile infection in PICU.This review aimed to analyze the advantages and disadvantages of preventive acid suppressant therapy and promote the rational use of acid suppressant in PICU.
