Classification and clinical roles of immune related-biomarkers in sepsis
10.3760/cma.j.issn.1673-4912.2022.12.001
- VernacularTitle:脓毒症免疫相关新型生物学标志物的分类及其临床意义
- Author:
Yucai ZHANG
1
;
Zihui LIU
;
Chunxia WANG
Author Information
1. 上海市儿童医院 上海交通大学医学院附属儿童医院重症医学科 200062
- Keywords:
Biomarker;
Classification;
Hyperinfammatory phenotype;
Immunosuppressive phenotype;
Sepsis
- From:
Chinese Pediatric Emergency Medicine
2022;29(12):941-945
- CountryChina
- Language:Chinese
-
Abstract:
Biomarkers of sepsis play critical roles in diagnosis, early recognition of organ dysfunction, risk stratification, prognostication, and therapeutic strategy.The dysregulated inflammatory response is reflected drastic changes in pathogen-associated molecular patterns and damage-associated molecular patterns, presented the changes of gene expression and epigenetic modification, metabolic reprogramming and immune dysfunction of immune cells.Sepsis is classified into hyperinflammatory phenotype and immunosuppression phenotype.Biomarker exploration is also conductive to understand the heterogeneity of sepsis and developing the individualized treatment strategies.This issue focused on novel immune-associated biomarkers for prognostic prediction that could be useful to optimize patient management.
