Research progress on the mechanisms of inflammasomes during respiratory infections
10.3760/cma.j.cn101070-20211230-01513
- VernacularTitle:炎症小体在呼吸道病毒感染中的作用机制研究进展
- Author:
Lexi LI
1
;
Gen LU
Author Information
1. 华南理工大学医学院，广州 510006
- Keywords:
Respirovirus;
Inflammasome;
NLRP3 inflammasome;
AIM2 inflammasome
- From:
Chinese Journal of Applied Clinical Pediatrics
2023;38(5):398-400
- CountryChina
- Language:Chinese
-
Abstract:
Acute respiratory infections are the most common infectious diseases in children.Among them, respiratory viruses are the main pathogens that cause many respiratory diseases, system damages or even death.As the first line of defense against pathogens like respiratory viruses, the innate immune system recognizes the structural components of viruses and endogenous danger signals with the pattern recognition receptors on immune cells and epithelial cells.During this process, inflammasomes are assembled and activated, and they participate in the recognition of viruses, inflammatory and immune response against viruses.The present study aims to describe the composition and function of inflammasomes, as well as the activation and negative regulation mechanisms of inflammasomes during common respiratory infections.
