Integration of traditional tests and biomarkers for the early diagnosis of neonatal necrotizing enterocolitis
10.3760/cma.j.cn101070-20220621-00747
- VernacularTitle:整合传统检查及生物学标志物优化新生儿坏死性小肠结肠炎的早期诊断
- Author:
Yongyan SHI
1
;
Jianhua FU
Author Information
1. 中国医科大学附属盛京医院儿内科，沈阳 110004
- Keywords:
Neonatal necrotizing enterocolitis;
X-ray;
Ultrasound;
Near-infrared spectroscopy;
Biomarker
- From:
Chinese Journal of Applied Clinical Pediatrics
2023;38(3):198-203
- CountryChina
- Language:Chinese
-
Abstract:
Necrotizing enterocolitis (NEC) is the most common and serious acute intestinal necrotizing disease in newborns, especially in preterm infants.Infants with smaller gestational age are more prone to NEC.NEC-related mortality reaches up to 20%-30%, and 25% of the survivors suffer from serious sequelae such as the short bowel syndrome, growth restriction and long-lasting neurological dysplasia.Due to the atypical symptoms, early diagnosis of NEC is difficult, and the patient′s condition has already been serious at the time of diagnosis in general.Ultrasound and abdominal X-ray are traditional tools for the diagnosis of NEC.Serum, urine and fecal biomarkers have been gradually applied to clinical practice in recent years.Through integrating traditional tests with biological markers and optimizing the clinical decision-making system for NEC, precise clinical diagnosis and individualized treatment can be achieved.
