Risk factors and complication of hemodynamically significant patent ductus arteriosus in preterm infants with gestational age <32 weeks
10.3760/cma.j.issn.1673-4408.2023.05.012
- VernacularTitle:胎龄<32周有血流动力学意义的动脉导管未闭早产儿危险因素及并发症分析
- Author:
Yu WANG
1
;
Yumin XU
;
Dan LI
;
Chunyan YANG
;
Ping XU
Author Information
1. 聊城市人民医院NICU 252000
- Keywords:
Infant, premature;
Patent ductus arteriosus;
Hemodynamics;
Risk factors
- From:
International Journal of Pediatrics
2023;50(5):344-347
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the risk factors and complications of hemodynamically significant patent ductus arteriosus(hsPDA)in preterm infants <32 weeks.Methods:From January 2021 to March 2022, a total of 150 premature infants with gestational age <32 weeks admitted to the Neonatal Intensive Care Unit of Liaocheng People′s Hospital were enrolled.Nine patients who did not meet the requirements were excluded and a total of 141 infants were finally analyzed retrospectively, including PDA group with 95 cases and non-PDA group with 46 cases.According to whether hsPDA existed or not, PDA group were dirided into hsPDA group with 42 cases and non-hsPDA group with 53 cases.Univariate and regression analyses were used to determine the risk factors and complication of hsPDA.Results:Univariate analysis showed that gestational age( t=-6.861, P<0.01), birth weight( t=-4.392, P<0.01), mode of delivery( χ2=9.018, P<0.01), caffeine( χ2=4.337, P<0.05) and suffocation( χ2=7.918, P<0.01)were associated with hsPDA.Logistic regression analysis showed that gestational age( OR=2.435, P<0.01, 95% CI: 1.669~3.552)was an independent risk factor for hsPDA in gestational age <32 weeks preterm infants.The incidences of necrotizing enterocolitis, intraventricular hemorrhage, bronchopulmonary dysplasia, and retinopathy of prematurity in the hsPDA group were higher than those in the non-hsPDA group( P<0.05). Conclusion:Gestational age is an independent risk factor for hsPDA with gestational age <32 weeks.Necrotizing enterocolitis, intraventricular hemorrhage, bronchopulmonary dysplasia, and retinopathy of prematurity are related complications of hsPDA.
