Progress in the mechanisms and preventive measures of cisplatin-induced ototoxicity
10.3760/cma.j.issn.1673-4408.2023.04.003
- VernacularTitle:顺铂诱导耳毒性的发生机制及预防措施研究进展
- Author:
Jiaxin PENG
1
;
Yijin GAO
Author Information
1. 上海交通大学医学院附属上海儿童医学中心血液肿瘤科 200127
- Keywords:
Cisplatin;
Ototoxicity;
Otoprotection
- From:
International Journal of Pediatrics
2023;50(4):229-233
- CountryChina
- Language:Chinese
-
Abstract:
Cisplatin is a broad-spectrum and highly effective chemotherapeutic agent, with a dose-dependent therapeutic effect.Unfortunately, high-does therapy is limited by ototoxicity, nephrotoxicity and neurotoxicity.Ototoxicity is a common and serious complication after cisplatin chemotherapy, which has greatly debilitating effect on patients′ quality of life.Currently, there are no FDA-approved drugs available to prevent cisplatin-induced hearing loss.In recent years, domestic and international studies on cisplatin-induced ototoxicity have revealed many new mechanisms and therapeutic targets.Many candidate agents have shown good hearing protection.Moreover, local drug delivery methods are being optimized, promising for further translations to clinical applications.
