Pediatric inflammatory bowel disease and oral microbiota
10.3760/cma.j.issn.1673-4408.2023.03.010
- VernacularTitle:儿童炎症性肠病与口腔微生物的关系
- Author:
Ting GE
1
;
Yizhong WANG
;
Ting ZHANG
Author Information
1. 上海市儿童医院 上海交通大学医学院附属儿童医院消化科 200062
- Keywords:
Inflammatory bowel disease;
Oral microbiota;
Crohn′s disease;
Ulcerative colitis
- From:
International Journal of Pediatrics
2023;50(3):186-189
- CountryChina
- Language:Chinese
-
Abstract:
The oral cavity is continuous with the gastrointestinal tract and oral health may be closely linked with the overall health of the gastrointestinal tract.Inflammatory bowel disease(IBD)is an intestinal disorder characterized by chronic inflammation of unknown etiology, affected by host genetics, immunoregulation, daily diet, and the gut microbiota.Recent studies of the microbiome in IBD suggest that translocation of oral microbes to the gut may be a common feature of the microbial dysbiosis which is a signature of both pediatric Crohn′s disease and ulcerative colitis.Murine studies suggest that translocation of oral bacteria and yeasts to the lower gastrointestinal tract may trigger inflammation in susceptible hosts, providing a mechanistic link to the development of IBD.Oral microbiota may play an important role in the development of IBD.This article reviews the relationship between oral microbiota and pediatric IBD.
