Progress on the mechanism of resistance of Streptococcus pneumoniae to β-lactam antibiotics and vaccine immunoprophylaxis
10.3760/cma.j.issn.1673-4408.2023.01.009
- VernacularTitle:肺炎链球菌对β-内酰胺类抗生素的耐药机制及疫苗免疫预防的研究进展
- Author:
Yaling LV
1
;
Ning LI
Author Information
1. 广东医科大学附属东莞儿童医院儿科 523325
- Keywords:
Streptococcus pneumoniae;
β-lactam antibiotics;
Drug resistance mechanism;
Vaccine
- From:
International Journal of Pediatrics
2023;50(1):42-46
- CountryChina
- Language:Chinese
-
Abstract:
Streptococcus pneumoniae(SP)is one of the common pathogens of respiratory tract infection in children, which can evolve into severe pneumonia and necrotizing pneumonia in case of severe infection.β-lactam antibiotics are the first-line treatment for SP.The resistance mechanism of SP to β-lactam antibiotics is mainly PBPs gene mutation, followed by mutations related to non-PBPs genes such as MurM, CpoA, TEM, CiaH/CiaR-TCSS and StkP-PhpP signal conjugations.Antibiotic selection pressure and vaccine-induced serotype substitution may influence SP resistance.Serotypes 19F and 19A have high resistance to β-lactam antibiotics, and promotion of PCV13 may be more beneficial than other SP vaccines in preventing SP infection in children.
