Study on the progress of HIV typing methods
10.19428/j.cnki.sjpm.2023.22863
- VernacularTitle:艾滋病病毒分型方法研究进展
- Author:
Qianru LIN
1
;
Yi LIN
1
;
Ping ZHONG
1
;
Xin SHEN
1
Author Information
1. Division of Tuberculosis and HIV/AIDS Control and Prevention， Shanghai Municipal Center for Disease Control and Prevention， Shanghai 200336 ，China
- Publication Type:Review
- Keywords:
HIV;
AIDS;
subtype;
typing method;
sequencing;
molecular epidemiology
- From:
Shanghai Journal of Preventive Medicine
2023;35(7):719-723
- CountryChina
- Language:Chinese
-
Abstract:
As a retrovirus with high recombination and mutation rate， HIV targets CD4+ T lymphocytes， causing damage to the body's immune system and eventually leading to severe immune function defects. Different subtypes of the HIV virus exhibit significant sequence differences in their structural and regulatory genes， and this diversity is closely related to etiology， transmission， diagnosis， drug therapy， disease progression， and vaccine development. As a country with the largest number of HIV subtypes， rapid and accurate typing of the HIV virus holds great significance for China's efforts in disease prevention and control. This study provides a comprehensive reveiw of domestic and international HIV genotyping methods， and summarizes the clinical significance of different subtypes in order to provide reference for further research.
