Analysis on Motion Characteristics of Red Blood Cells in Capillaries
10.16156/j.1004-7220.2023.01.18
- VernacularTitle:红细胞在毛细血管中的运动特征分析
- Author:
Deyun LIU
1
;
Xiaobo GONG
1
Author Information
1. School of Naval Architecture, Ocean & Civil Engineering, Shanghai Jiao Tong University
- Publication Type:Journal Article
- Keywords:
red blood cell ( RBC);
large deformation;
fluid-structure interaction;
immersed boundary method;
capillary;
non-axisymmetric deformation
- From:
Journal of Medical Biomechanics
2023;38(1):E123-E128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the motion and deformation of red blood cells ( RBCs) with different mechanical properties in capillaries,and make analysis on the associated hemorheological parameters. Methods The RBC was modeled as a hyper elastic membrane using Skalak model. The fluid was solved using a two-order difference scheme with the membrane mechanics treated by the immersed method. The pathological viscosity ratio λ= 5 was considered. Results The steady deformation of RBCs with different membrane stiffness in the capillary was obtained. With membrane stiffness increasing, the cell transformed from axisymmetric shapes to non-axisymmetric shapes. With capillary number increasing, the deformability of RBCs weakened and the flow resistance increased. Conclusions With stiffening of cell membrane, the non-axisymmetric cell shape appears and the flow resistance increases. Therefore, in diseases involved stiffening RBCs, the stiffened RBCs can cause the blockage of capillaries and hypoxia in surrounding tissues.
