Progress of Biomarkers to Predict Response to Immune Checkpoint Inhibitors in Microsatellite Stability Colorectal Cancer
10.3971/j.issn.1000-8578.2023.22.0736
- VernacularTitle:微卫星稳定型结直肠癌免疫检查点抑制剂疗效预测标志物研究进展
- Author:
Zhiqiang WANG
1
;
Shuai DONG
;
Menglong LI
;
Rui LIANG
Author Information
1. Department of Anorectal Surgery, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
- Publication Type:Research Article
- Keywords:
Microsatellite stable;
Colorectal cancer;
Immunotherapy;
Immune checkpoint inhibitors;
Predictive biomarker
- From:
Cancer Research on Prevention and Treatment
2023;50(2):186-190
- CountryChina
- Language:Chinese
-
Abstract:
The exploration of biomarkers predicting response to immune checkpoint inhibitors in microsatellite stability colorectal cancer can enable more patients to benefit from immunotherapy. Tumor mutational burden (TMB), POLE/POLD1 mutation, CMS classifications, MGMT methylation, and other indicators own the potential and value of predicting response to immune checkpoint inhibitors in microsatellite stability colorectal cancer. In this paper, we reviewed the related research on predictive biomarkers of immune checkpoint inhibitors in microsatellite stability colorectal cancer, provide a reference for the best treatment strategy for microsatellite stability colorectal cancer.
