Efficacy and Safety of Anlotinib Combined with PD-1 Blockades for Patients with Advanced Epithelial Ovarian Cancer
10.3971/j.issn.1000-8578.2022.22.0211
- VernacularTitle:安罗替尼联合PD-1抑制剂后线治疗晚期上皮性卵巢癌的疗效及安全性分析
- Author:
Huimin JIN
1
;
Lihong LIN
;
Zhen ZHAO
;
Xishuang GONG
Author Information
1. Department of Gynecology, Anyang Tumor Hospital, Anyang 455000, China
- Publication Type:Research Article
- Keywords:
Epithelial ovarian cancer;
Anlotinib;
PD-1 blockade;
Efficacy;
Adverse effect
- From:
Cancer Research on Prevention and Treatment
2022;49(10):1059-1064
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of anlotinib combined with PD-1 blockades for patients with advanced epithelial ovarian cancer (EOC). Methods A retrospective study was performed, enrolling 33 patients with advanced EOC who failed standard systematic therapy. All patients were administered with anlotinib combined with PD-1 blockades. The efficacy and safety profile were determined during treatment. Results The objective response rate of the 33 patients was 36.4% (95%CI: 20.4%-54.9%) and the disease control rate of the patients was 81.8% (95%CI: 64.5%-90.0%). The median PFS and OS of the 33-patient cohort were 7.6 months (95%CI: 3.1-12.1) and 19.6 months (95%CI: 15.1-24.1), respectively. The most common treatment-related adverse reactions were fatigue (66.7%), nausea and vomiting (54.5%), hypertension (48.5%), and diarrhea (39.4%). Furthermore, multivariate Cox regression analysis indicated that ECOG performance status and FIGO stage were independent factors for predicting the PFS of the combination regimen for patients with advanced EOC. Conclusion Anlotinib combined with PD-1 blockades preliminarily exhibit satisfactory efficacy and tolerable safety profile for patients with advanced EOC.
