Research Progress on Roles of lncRNA as ceRNA in EMT of Gastric Cancer

VernacularTitle:长链非编码RNA作为ceRNA在胃癌上皮间质转化中的作用研究进展
Author: Yinbing TANG ¹ ; Heteng ZHANG ; Wenbo ZHANG ; Pengcheng JIANG
Author Information

1. Department of General Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212002, China
Publication Type:Research Article
Keywords: Gastric cancer; Long non-coding RNA; ceRNA; Epithelial-mesenchymal transition
From: Cancer Research on Prevention and Treatment 2022;49(4):352-358
CountryChina
Language:Chinese
Abstract: Gastric cancer is one of the most common malignant tumors in the world, and EMT plays a key role in the development and metastasis of gastric cancer. The regulation of EMT is a complex network. Transcription factors such as SNAIL/SLUG, Twist1/2 and ZEB1/2 play an important induction role in the process of tumor EMT. In addition, the regulation of EMT is related to the participation of cytokines and miRNAs (such as miR-200 family). In recent years, with the deepening studies on non-coding RNAs, researchers discovered that ceRNA networks, involving lncRNA, circRNA, miRNA, mRNA and other RNA molecules, can extensively regulate the proliferation and metastasis of tumor cells, and are closely related to EMT. This paper reviews the role and molecular mechanism of lncRNA as ceRNA in EMT of gastric cancer, to deepen the understanding of ceRNA network in gastric cancer and other malignant tumors.