Meta-analysis of Ac-SDKP inhibition of Pulmonary fibrosis in animal models.
10.3760/cma.j.cn121094-20211115-00565
- VernacularTitle:Ac-SDKP抑制动物模型肺纤维化的Meta分析
- Author:
Hai Bo GONG
1
;
Cheng Mei ZHANG
1
;
Xin Yan TANG
1
;
Ruo Bing GONG
1
;
Zhi Ying MIAO
1
;
Hai Jing DENG
1
Author Information
1. School of Basic Medical Sciences, North China University of Science and Technology, Hebei Key Laboratory for Chronic Diseases, Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, Tangshan 063210, China.
- Publication Type:Journal Article
- Keywords:
Animal model;
Meta-analysis;
N-acetyl-seryl-aspartyl-lysyl-proline;
Pulmonary fibrosis;
Silicosis
- MeSH:
Rats;
Animals;
Pulmonary Fibrosis;
Rats, Wistar;
Fibrosis;
Disease Models, Animal;
Proline
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2023;41(4):262-270
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To systematically study the anti-fibrotic effect of N-acetyl-seryl-as partyl-lysyl-proline (Ac-SDKP) on pulmonary fibrosis. Methods: In May 2021, a computer search was performed on CNKI, Wanfang Knowledge Service Platform, VIP.com, China Biomedical Literature Database, Pubmed, OVID and other databases. The retrieval time was from January 2008 to May 2021. Randomized controlled experiments on the inhibition of pulmonary fibrosis by Ac-SDKP were screened. The control group was the pulmonary fibrosis model group and the experimental group was the Ac-SDKP treatment group. The quality of the literature was assessed using the syrcle risk of bias assessment tool, and data were extracted. Data analysis was Performed using revman 5.4 software. Results: 18 papers were included, with a total of 428 animal models. The results of meta analysis showed that the contents of α-smooth muscle actin (α-SMA), type I collagen, type Ⅲ collagen, transforming growth factor-β (TGF-β) and Nodule area in the exPerimental group were lower than those in the control grouP. [SMD=-2.44, 95%CI (-3.71--1.17), P=0.000][SMD=-5.36, 95%CI (-7.13--3.59), P=0.000] [SMD=-3.07, 95%CI (-4.13--2.02), P<0.000][SMD=-2.88, 95%CI (-3.63--2.14), P=0.000] [SMD=-1.80, 95%CI (-2.42--1.18), P=0.000], the content of hydroxy proline in the experimental group was higher than that in the control group [SMD=7.62, 95%CI (4.90-10.33), P=0.000], all indexes included in the literature were statistically significant. Conclusion: Ac-SDKP has obvious inhibitory effect on the process of pulmonary fibrosis, and may become a new clinical drug for the treatment of pulmonary fibrosis.
